TASQUINIMOD SUPPRESSES TUMOR CELL GROWTH AND BONE RESORPTION BY TARGETING IMMUNOSUPPRESSIVE MYELOID CELLS AND INHIBITING C-MYC EXPRESSION IN MULTIPLE MYELOMA

Background Immunotherapy emerged as a promising treatment option for multiple myeloma (MM) patients.However, therapeutic efficacy can be hampered by the presence of an immunosuppressive bone marrow microenvironment including myeloid cells.S100A9 was previously identified as a key regulator of myeloid cell accumulation and suppressive activity.Tasqu

Nowadays, engine room simulators have become an important tool for maritime training, but programming engine room simulators often involves handling large amounts of data, making the process inefficient.This paper proposes an innovative visual modeling method for the ship pipeline network program in engine room jolly rancher filled gummies simulato

The transformation of managerial decision-making processes in the digital economy, the modification of the boundaries of the personal space of an employee and bekindtopets.com manager (manager) when making collegial decisions through social networks and other modern communication tools have been investigated.The problems of assessing the quality of

Nacre is a biological material constituting the innermost layer of the shells of gastropods and bivalves.It consists of polygonal tablets of aragonite, tessellated to form individual layers and having the adjacent layers as well as the tablets within a layer bonded by a biopolymer.Due to its highly complex hierarchical microstructure, nacre possess